Michigan vs Ohio State Odds & Prediction for College Football 2025

Dan Thompson Profile Picture
Fact Checked by Editorial Staff
Michigan vs. Ohio State at Michigan Stadium

The Ohio State-Michigan rivalry is one of the most storied in all of college football. This year's game marks the 121st meeting between the two Blue-Blood programs, and Michigan is looking to win its fifth consecutive matchup against Ohio State. Can the reigning national champions finally overcome their rivals? Below, we broke down everything that the best Ohio sportsbook has to say about this highly anticipated matchup.

Latest Michigan vs Ohio State Odds

Ohio State will travel to Ann Arbor to take on Michigan on November 29. Like always, this is the final game of the 2025-26 college football regular season. Ohio State is a 19.5-point favorite at the start of the season.

🔢 MICH vs OSU SpreadOSU -19.5
📊 MICH vs OSU MoneylineOSU -2800, MICH +1200
📈 MICH vs OSU Over/Under42.5 (-105/-115)
✅ Odds Last VerifiedSeptember 12, 2025

Who is Favored in Michigan vs Ohio State? 

Ohio State is currently favored by 19.5 points, according to FanDuel Sportsbook Ohio. Both teams are expected to be contenders for the CFP, but it will all come down to season performance and key player health. The Wolverines have a slight advantage with the game being in Michigan, but depending on how each team performs throughout the 2025 season, these odds will change wildly. Ohio State is off to a 2-0 start, while Michigan sits at 1-1.

Betting Promos for Michigan vs Ohio State

There are no specific betting promos currently available for the Michigan vs Ohio State game. However, bettors in Ohio can still take advantage of various welcome offers and Ohio sportsbook promos, allowing them to use bonus bets on this highly anticipated matchup. You should be able to bet the spread, moneyline, over/under, and various prop bets.

Michigan vs Ohio State Prediction

The 2025 Michigan vs. Ohio State game is shaping up to be another fierce showdown between two of college football’s most historic programs. Michigan has won the last four matchups and enters the season with a strong foundation, featuring key returning players and an impressive 2025 recruiting class. After missing the CFP last season, the Wolverines will be motivated to make a statement, and their competitive defense is expected to deliver an elite performance.

On the other side, Ohio State’s offense will be led by quarterback Julian Sayin, running backs James Peoples and CJ Donaldson, wide receivers Jeremiah Smith and Carnell Tate, and a sturdy offensive line. This explosive unit could pose a major challenge for Michigan’s defense.

OSU's defense has seen a lot of changes since last season after losing key players. After recruiting top talent, Ohio's defense could pose a serious challenge to Michigan's new quarterback and offense. If the secondary can contain Michigan's passing attack and limit their run game, the Wolverines' offense could be shut down.

Given Ohio State's motivation to end its losing streak against Michigan and Michigan's drive to rebound after missing the playoffs, this matchup promises plenty of excitement with possible playoff implications. Sportsbooks list the Buckeyes as early favorites, and we predict Ohio State will take the win by a touchdown.

Michigan vs Ohio State Pick: 

  • MICH: 17 | OSU: 37

When is the Michigan vs Ohio State Game?

In their annual end-of-the-year match-up, Ohio State and Michigan will play on November 29th. The Michigan vs Ohio State game is known as "The Game" and will be one of the most featured match-ups for Week 15. This game is always one of the most high-profile matchups of the college football season, and one of the most heavily bet on by fans.

Where is Michigan vs Ohio State Being Played?

The Buckeyes will head to Ann Arbor and play at Michigan Stadium in their 121st match-up. In their history, Michigan leads the series 32-24-4 in games at Michigan Stadium. The last time Ohio State beat Michigan on the road was back in 2018.

How to Watch Michigan vs Ohio State

The Ohio State vs Michigan game kicks off at noon ET in Ann Arbor, Michigan, and will be televised on Fox. You can stream "The Game" through various services, such as Hulu + Live TV, Fubo, or any other streaming service that carries Fox.

Michigan vs. Ohio State History

Games Played:120
First Game:1897: Michigan 34 | Ohio State 0
Last Game:2024: Michigan 13 | Ohio State 10
Next Game:November 29, 2025 at Michigan Stadium in Ann Arbor, MI
All-Time Record:Michigan 62 | Ohio State 52 | Ties 6

Ohio State v Michigan Odds & Prediction FAQ

Author

Dan Thompson

Dan Thompson is a Lead Betting Analyst for BetOhio.com. Dan's unique experience makes him the perfect fit to find the latest storylines and interesting betting angles impacting Ohio sports betting.

Cited by leading media organizations, such as: