Running Back Rankings: Who Will Lead RBs in Fantasy Football Week 4?

Fact Checked by Pat McLoone

The top two running backs in the NFL are the top two running backs you should consider starting as you prepare your fantasy lineups. Every Wednesday, — your source for Ohio sports betting — releases hypothetical odds on which RB will lead the league in fantasy points (standard PPR) this week. Here is the lay of the land for the week: 

Week 4 Fantasy RB Odds

PlayerOpponentOddsPercent Chance
🏈 Christian McCaffrey vs. Cardinals +35022.2%
🏈 D'Andre Swift vs. Commanders +41519.4%
🏈 Tony Pollard vs. Patriots +57014.9%
🏈 Raheem Mostert at Bills +62513.8%
🏈 Kenneth Walker at Giants +75011.8%


21+ and present in OH. Gambling Problem? Call 1-800-GAMBLER. In partnership with MGM Northfield Park

49ers’ McCaffrey Best Bet Again

The top rusher in the league is the San Francisco 49ers’ Christian McCaffery. Again, we forecast McCaffrey to be the best bet as a fantasy back and place +350 odds, 22.2% likelihood he posts big numbers against the Arizona Cardinals Sunday (FOX, 4:25). Tipico Ohio very much sees the 49ers staying unbeaten by making them a 14-point and -1000 moneyline favorite against the Cardinals. Through three games, McCaffrey has 60 carries for 353 yards and two touchdowns.

Philadelphia Eagles running back D’Andre Swift (+415, 19.4%) is the No. 2 choice for the week as the Eagles host the Washington Commanders on Sunday (FOX, 1). Swift is coming off a 16-carry, 130-yard performance in a 25-11 road win at the Tampa Bay Buccaneers on Monday. Swift is the league’s second leading rusher with 308 yards on 45 rushes and one score.

Rounding out the top five: Tony Pollard (+570, 14.9%) and the Dallas Cowboys will host the New England Patriots; the Miami Dolphins’ Raheem Mostert (+625, 13.8%) will visit the Buffalo Bills; and the Seattle Seahawks’ Kenneth Walker (+750, 11.8%) will visit the New York Giants on Monday night.

First Deposit Only. Must be 21+ and present in OH. Gambling Problem? Call 1-800-GAMBLER. First time depositors only. T&Cs apply.

Ohio RBs in Top 20

With Cleveland Browns star running back Nick Chubb (28 carries, 170 yards) out for the season due to injury, the Browns’ depth chart came into play and backup running back Jerome Ford has filled in nicely. Ford sits 17th in league rushing with 41 carries for 160 yards and one TD, highlighted by a 16-rush, 106-yard performance against the Steelers (after replacing Chubb) in a 26-22 road loss in Week 2.

Cincinnati Bengals running back Joe Mixon posted his highest numbers of the season in a 19-16 home victory over the Los Angeles Rams on Monday night. Mixon, 14th in the league's rushing stats, had 19 carries for 65 yards and one TD in the win. Cincinnati (1-2) will visit the Tennessee Titans (1-2) Sunday (FOX, 1). Be sure to have one of our Ohio sportsbook promo codes on hand before you place a Week 4 wager.

OH only. 21+. New users and first wager only. Must register with eligible promo code. Bet amount of qualifying wager returned only if wager is settled as a loss. Must be used within 14 days of receipt. See for full terms. Void where prohibited. Know When To Stop Before You Start.® Gambling problem? Call 1-800-GAMBLER


Lou Monaco

Lou Monaco had been East Coast Scene columnist for Gaming Today in Las Vegas since June 2019, covering the East Coast sportsbook scene with emphasis on NJ and PA. He also currently is a part-time writer for the high school sports department for NJ Advanced Media ( in Iselin, NJ. Lou has over 30 years sports experience with previous stints at ESPN SportsTicker, Daily Racing Form and Oddschecker.

Cited by leading media organizations, such as:

Scroll to top