Bengals vs Browns Odds & Prediction for Week 1

Bengals vs Browns Odds & Prediction for Week 1: Who is Favored to Win?

Key Takeaways:

🥇 Favorite: The Bengals are 5.5-points favorites over the Browns in Week 1.

🔥 Chances to Win: The Bengals have a 68.8% chance to win the game.

📊 2024 Record: The Browns fell to the Bengals in both 2024 matchups.

📈 Overall Record: The Bengals lead the overall series 55-48.

The Cincinnati Bengals and Cleveland Browns meet twice this season, starting right out of the gate in Week 1. Cleveland opens at home, marking Joe Flacco’s first regular-season start as the Browns’ quarterback. Early odds have the Bengals favored, and on paper, they look like the stronger side. This matchup isn’t just about bragging rights, it’s an early chance to gain ground in a tight AFC North race.

Here’s a look at the latest Bengals vs. Browns Week 1 odds, from the spread and moneyline to key props and more, plus what those lines say about how this matchup could play out.

Bengals vs Browns Odds: Quick Facts

Week 1 features eight divisional games, meaning half of the 2025 NFL season openers come with rivalry stakes. Here’s a look at the latest odds for the Bengals vs Browns showdown.

⭐ Favorite	Bengals
⚖️ Bengals Win	68.8% Chance
🔢 Point Spread	CIN -5.5
📊 Moneyline	CIN -220\| CLE +184
📈 Game Total	O/U 47.5 (-115/-105)
✅ Last Verified	September 16, 2025

Odds via FanDuel Sportsbook Ohio.

Who is Favored to Win?

The Cincinnati Bengals are listed as the favorites to win Week 1, according to the best Ohio sportsbooks.. Last season, the Browns went 0-2 against Cincinnati, giving the Bengals a recent track record of dominance. With Joe Burrow leading the offense and key playmakers on the roster, Cincinnati is expected to take control. Below, we break down the latest odds and what they mean for the Bengals vs Browns 2025 Week 1 matchup.

What is the Spread?

The Bengals are 5.5-point favorites on the road against the Browns, signaling that oddsmakers see Cincinnati as the better team. With home-field advantage generally worth about three points, being favored in Cleveland suggests the Bengals have a significant edge. We expect Cincinnati to win by a touchdown or more.

Breaking Down Moneylines

The Bengals are -220 favorites on the moneyline against the Browns, while Cleveland sits at +184. Even with the game in Cleveland, it’s no surprise that Joe Burrow and company are favored to win. Cincinnati’s talented roster and recent success against the Browns make them the team to beat, and we anticipate the Bengals coming out on top.

Game Total: Over/Under

The over/under for this game is set at 47.5, according to Fanatics Sportsbook Ohio. In the last matchup between these two teams, the over/under was set at 46.5, but the game finished with just 35 total points, well under the mark. We expect the total to hit the under again in this matchup.

Bengals vs Browns Prediction

The Bengals swept the Browns last season, winning both matchups. But 2025 brings new pieces, including the Browns starting veteran QB Joe Flacco. With Myles Garrett back in Cleveland, the Bengals will need to protect Joe Burrow to maintain their winning streak against the Browns. We expect Cincinnati to come away with a win and put up a high-scoring performance.

How to Bet on the Game

Bettors have no shortage of options if they're looking to wager on the NFL. There are plenty of Ohio betting apps that offer a variety of markets before the start of the season and even more during the season.

We recommend using a platform like Caesars Sportsbook Ohio, as this operator tends to have one of the largest selections of in-game markets for regular-season matchups.

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As of the writing of this article, there are no specific Bengals-Browns promos for the 2025 season. But we recommend surveying the market for the best sign-up bonus, as you can use a standard Ohio sportsbook promo to wager on whatever you want.

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How to Watch the Game

The Bengals vs Browns game on September 7 will air on FOX. Fans in local markets can watch on FOX through live TV streaming services like Fubo, Hulu + Live TV, or YouTube TV. If you’re out of market, the NFL+ app lets you stream live local and primetime regular-season games.

History of Browns vs Bengals

Denzel Ward defends pass against Ja'Marr Chase

These two division rivals have a long history, even if Cleveland has had the edge recently. Below, we broke down everything you need to know about the history between these two teams.

Browns vs Bengals All-Time Record

Games Played:	103
Bengals Wins:	55
Chiefs Wins:	48
Ties:	0
Playoff Matchups:	2
Super Bowl Matchups:	0
First Matchup:	1970
Last Matchup:	2024

Last 5 Times They Played

Date	Matchup	Winner
12/22/2024	CLE @ CIN	CIN (24-6)
10/20/2024	CLE vs CIN	CIN (21-14)
1/7/2024	CLE @ CIN	CIN (31-14)
9/10/2023	CLE vs CIN	CLE (24-3)
12/11/2022	CLE @ CIN	CIN (23-10)

Browns vs. Bengals Game FAQs

For Week 1, most Ohio sportsbooks list the Cincinnati Bengals as 5.5-point favorites over the Cleveland Browns, with the over/under set at 47.5 points. With Cincinnati’s high-powered offense, we anticipate a fast-paced, high-scoring matchup.

The Bengals and Browns face off twice each regular season. Cincinnati opens 2025 in Cleveland for Week 1 and will close out the season hosting the Browns in Week 18. Both games carry added importance in the tight AFC North race.

The Bengals are favored to win the Week 1 matchup against the Browns on September 7. With a -220 moneyline, Cincinnati has a 68.8% chance of defeating Cleveland, while the Browns’ +184 odds imply about a 35.2% chance of an upset.

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The experts at BetOhio who bring you the latest updates in Ohio sports betting. We pull together decades of experience to give you analysis as well as comparisons of the best OH online gambling apps.